The immunosuppressive effects of morpbine were investigated in our previous work in vivo and in vitro. The apoptosis of mature and immature T-cell was observed presently to study the possible role of T-cell death in the mechanism of. immunosuppression produced by morphine. Administration of morphine subcutaneously to Balb/c mice of 3-wk old for 1, 5, or 10 d continually at a dose of 0, 6.25, 12.5, 25, 50, 100 mg kg~(-1) (bid) showed an exciting activities (circling around the cage) of mice at least 1 h after injection (in all doses since the The immunosuppressive effects of morpbine were investigated in our previous work in vivo and in vitro. The apoptosis of mature and immature T-cell was observed presently to study the possible role of T-cell death in the mechanism of. Immunosuppression produced by morphine. Administration of morphine subcutaneously to Balb / c mice of 3-wk old for 1, 5, or 10 d continually at a dose of 0, 6.25, 12.5, 25, 50, 100 mg kg ~ (bid) showed an exciting activities (circling around the cage) of mice at least 1 h after injection (in all doses since the