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目的:研究外伤性脑梗死患者血小板P选择素动态变化的临床意义。方法:用流式细胞仪测定42例外伤性脑梗死患者,50例无脑梗死外伤患者及40例正常对照者外周血血小板P选择素。结果:急性期(1周内)外伤性脑梗死患者P选择素明显高于无梗死脑外伤患者和健康对照组(P<0.01)。14 d时,外伤性脑梗死患者血小板P选择素表达,与无梗死脑外伤患者和健康对照组无显著差异(P>0.005)。结论:P选择素参与外伤性脑梗死的病理过程,测定它们有利于外伤性脑梗死的早期诊治,改善预后。
Objective: To study the clinical significance of platelet P-selectin in patients with traumatic cerebral infarction. Methods: Peripheral blood platelet P-selectin was detected by flow cytometry in 42 patients with traumatic cerebral infarction, 50 patients without cerebral infarction and 40 normal controls. Results: P-selectin in acute phase (1 week) traumatic cerebral infarction was significantly higher than that in non-infarcted brain trauma patients and healthy controls (P <0.01). At 14 days, the expression of platelet P-selectin in patients with traumatic cerebral infarction had no significant difference (P> 0.005) as compared with those in non-infarcted traumatic brain injury patients and healthy controls. CONCLUSION: P-selectin is involved in the pathological process of traumatic cerebral infarction. It is helpful for the early diagnosis and treatment of traumatic cerebral infarction to improve the prognosis.