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目的观察手足口病的临床特征,加强对该病尤其是重症病例的认识。方法对2009年1月至2009年10月就诊的86例手足口病的临床资料进行回顾性分析,探讨其流行病学、临床特征和治疗转归等。结果 86例患儿中男48例,女38例;平均年龄3.2岁。72例为入托患儿。51例有明确手足口病接触史。患儿均有手足部位水疱样皮疹及口腔黏膜疱疹等典型临床表现。WBC升高35例(40.7%),WBC下降26例(30.2%);心肌酶增高32例(37.2%);CRP32例(37.2%)增高;血糖增高1例;心电图检查32例,其中5例有ST-T改变;X线胸片示双肺透光度减低3例;脑脊液检查4例,其中1例脑脊液白细胞数增高。均经常规利巴韦林抗病毒及对症处理,86例(包括合并脑炎5例,其中危重症1例)均获痊愈,平均住院时间7.2d。结论手足口病多发生于3岁以下幼儿,大多预后良好,重症患儿应早期发现,及时救治,以减少病死率。
Objective To observe the clinical features of hand, foot and mouth disease and strengthen the understanding of the disease, especially severe cases. Methods The clinical data of 86 cases of HFMD treated from January 2009 to October 2009 were analyzed retrospectively to investigate the epidemiology, clinical characteristics and treatment outcome. Results 86 cases of children, 48 males and 38 females; mean age 3.2 years. 72 cases were admitted to children. 51 cases have a clear history of hand, foot and mouth disease. Children have both hand and foot blister-like rash and oral mucosal herpes and other typical clinical manifestations. WBC increased in 35 cases (40.7%), WBC decreased in 26 cases (30.2%), myocardial enzymes increased in 32 cases (37.2%), CRP increased in 37 cases (37.2%), increased blood glucose in 1 case, electrocardiogram in 32 cases There are ST-T changes; X-ray showed decreased lung transplance in 3 cases; 4 cases of cerebrospinal fluid examination, including 1 cases of cerebrospinal fluid leukocyte increased. Both routine ribavirin antiviral and symptomatic treatment, 86 cases (including 5 cases of merger encephalitis, including 1 critically ill) were cured, the average length of stay 7.2d. Conclusion Hand-foot-mouth disease occurs mostly in children under 3 years of age, most of the prognosis is good, severe cases should be found early, timely treatment to reduce mortality.