研究川芎嗪对大鼠急、慢性缺氧性肺动脉高压的作用及其对血液动力学和心功能其它指标的影响。结果表明,川芎嗪(80mg/kg体重)作为一种新型的钙拮抗剂能显著抑制由急、慢性缺氧导致的肺动脉升压反应;无论在急性还是慢性缺氧情况下,川芎嗪对右心室|±dp/dtmax|都无显著影响,提示川芎嗪既能扩张肺血管又能保护心脏功能,是一种理想的抗缺氧性肺动脉高压的药物。 To investigate the effect of ligustrazine on acute and chronic hypoxic pulmonary hypertension in rats and its influence on other indexes of hemodynamics and cardiac function. The results showed that ligustrazine (80mg / kg body weight) as a new type of calcium antagonist can significantly inhibit the acute and chronic hypoxia-induced pulmonary arterial pressure response; both acute and chronic hypoxia, tetramethylpyrazine on the right ventricle | ± dp / dtmax | had no significant effect, suggesting that tetramethylpyrazine can both expand pulmonary blood vessels and can protect cardiac function, is an ideal anti-hypoxic pulmonary hypertension drug.