肾病综合征(以下简称NS)合并血栓栓塞(TEC)的发生率很高,成年为19～70%,儿科尚无记载。本文研究NS的凝血因子,并用闪烁法阐明了TEC的发生率。病人和方法本文研究了16例对类固醇敏感的急性复发NS儿童的凝血因子。有α_2巨球蛋白(α_2-M)、C_1灭活因子(Cl 1n)、α_1-抗胰蛋白酶(α_1-AT)和抗凝血酶Ⅲ(AT-Ⅲ)、AT-Ⅱ活性、纤维蛋白原、Ⅷ:R:AG因子、血纤维蛋白溶酶原(PLG)和α_2-抗血纤维蛋白酶(α_2-AP)。12例做了肾活检,均显示为微小病变型(MCNS),在激素治疗前取血标本。另对26名NS儿童(平均8.4岁)的TEC做了回顾性研究。9名属于MCNS频发者;14名曾用细胞毒 Nephrotic syndrome (hereinafter referred to as NS) with high incidence of thromboembolism (TEC), adult 19 to 70%, there is no record of pediatrics. This article studies the clotting factor of NS, and elucidates the incidence of TEC by scintigraphy. PATIENTS AND METHODS In this study, 16 coagulation factors of acute steroid-responsive NS children with acute relapse were studied. Α 2 -M, C 1 inactivating factor (Cl 1n), α 1-antitrypsin (α 1 -AT) and antithrombin Ⅲ (AT-Ⅲ), AT-Ⅱ activity, fibrinogen , Ⅷ: R: AG factor, plasminogen (PLG) and α_2-anti-fibrinolytic enzyme (α_2-AP). Twelve patients underwent renal biopsy, all showing minimal disease (MCNS), with blood taken prior to hormone therapy. A retrospective study was also performed on TEC of 26 NS children (average 8.4 years). Nine were MCNS frequent carriers; 14 were previously cytotoxic