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[目的]探讨妊娠期肝内胆汁淤积症(ICP)孕妇血清甘胆酸(CG)水平变化与围生儿预后的关系。[方法]应用放射免疫法测定60例妊娠期肝内胆汁淤积症患者ICP组)与30例正常孕妇(对照组)的血清SCG水平,观察记录胎儿预后情况,对二者的关系进行分析。[结果]轻度ICP组和重度ICP组血清CG水平均明显高于对照组(P﹤0.05),且轻度ICP组和重度ICP组比较,血清CG水平差异也有统计学意义(P﹤0.05);随着血清CG值的升高,胎儿窘迫、早产、死产、羊水污染及新生儿窒息的发生率均显著增高(P﹤0.05)。[结论]血清CG水平与围生儿预后不良密切相关,随着血清CG水平的增高预示围生儿预后不良。
[Objective] To investigate the relationship between the levels of serum glycocholic acid (CG) in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and the prognosis of perinatal infants. [Method] The serum SCG levels in 60 patients with intrahepatic cholestasis of pregnancy (ICP) group and 30 normal pregnant women (control group) were measured by radioimmunoassay. The relationship between them was analyzed by observing the fetal prognosis. [Results] The levels of serum CG in mild ICP group and severe ICP group were significantly higher than those in control group (P <0.05). There was also a significant difference in serum CG levels between mild ICP group and severe ICP group (P <0.05) ; With the increase of serum CG value, the incidence of fetal distress, premature birth, stillbirth, amniotic fluid contamination and neonatal asphyxia were significantly increased (P <0.05). [Conclusion] The level of serum CG is closely related to the poor prognosis of perinatal children. With the increase of serum CG level, the prognosis is poor.