论文部分内容阅读
目的 探讨血浆可溶性白细胞介素 2受体 (sIL -2R)及一氧化氮 (NO)在Graves’病 (GD)中的作用及意义。方法 选取初诊GD患者 2 2例 ,并在其缓解后分别检测血浆sIL -2R、NO水平 ,分别与对照组作比较。sIL -2R采用双抗体酶联免疫夹心法 (ELISA)、NO采用Griess比色法。结果 GD患者血浆sIL -2R、NO水平明显高于缓解组及对照组 ,分别有极显著性差异 (P <0 0 1)和显著性差异 (P <0 0 5 ) ,缓解组和对照组比较差异无显著性 (P >0 0 5 )。结论 随着GD病情的好转 ,sIL -2R、NO水平逐渐降至正常 ,说明sIL -2R、NO参与了GD的病理过程 ,并可作为GD病人病情诊断、疗效观察的一项有用指标
Objective To investigate the role and significance of soluble interleukin 2 receptor (sIL-2R) and nitric oxide (NO) in Graves’ disease (GD). Methods Twenty-two patients with newly diagnosed GD were enrolled and their plasma levels of sIL-2R and NO were measured respectively after their relief. The levels were compared with the control group respectively. sIL -2R using double antibody enzyme-linked immunosorbent assay (ELISA), NO using Griess colorimetric method. Results The plasma level of sIL-2R and NO in patients with GD were significantly higher than those in control group and remission group (P <0.01) and significant difference (P <0 05) There was no significant difference (P> 0.05). Conclusions With the improvement of GD, the levels of sIL-2R and NO gradually decreased to normal, indicating that sIL-2R and NO are involved in the pathological process of GD and may be used as a useful indicator for the diagnosis and curative effect of GD