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T2DM骨骼肌线粒体含量减少,是否高血糖抑制线粒体生物合成和/或功能尚不清楚。本文研究不同血糖水平对T2DM患者肌肉线粒体功能的影响:T2DM患者11例,男9例,女2例,年龄52.8±2.5岁,BMI 30.2±1.1 kg/m~2,用胰岛素(Aspart+NPH)平均46天(31～59天),血糖控制不良,治疗前后测线粒体呼吸与乳酸合成酶活性(Citrate synthase activity,一种线粒
T2DM skeletal muscle mitochondrial content is reduced, whether hyperglycemia inhibits mitochondrial biosynthesis and / or function is unclear. In this paper, we studied the effects of different blood glucose levels on muscle mitochondrial function in T2DM patients: 11 patients with T2DM, 9 males and 2 females, aged 52.8 ± 2.5 years, with BMI 30.2 ± 1.1 kg / m ~ 2 and insulin (Aspart + NPH) Average 46 days (31 ~ 59 days), poor glycemic control before and after treatment measured mitochondrial respiration and lactate synthase activity (Citrate synthase activity,