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1942年Becker等报道胰岛细胞恶性肿瘤可伴皮肤游走性红斑、舌炎、贫血及糖尿病。1960年Gossner从一例类似病人的肿瘤组织中提取到一种致高血糖物质——可能即系胰高糖素。McGavran等证实胰岛A细胞肿瘤组织中含有大量胰高糖素,且伴有血浆胰高糖素升高,故提出了“胰高糖素瘤”的概念。Wilkinson在一例“牛皮癣”患者中测得其血浆胰高糖素极
Becker et al. Reported in 1942 that pancreatic islet cell malignancies may involve erythema, glossitis, anemia and diabetes in the skin. In 1960 Gossner extracted a hyperglycemic substance from a tumor-like tissue in a patient-probably glucagon. McGavran confirmed that islet A cell tumor tissue contains a lot of glucagon, and associated with elevated plasma glucagon, it put forward the concept of “glucagon tumor.” Wilkinson measured plasma glucagon in a patient with “psoriasis.”