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1990年以来,美国Lawrence Livermore国家实验室的许多研究报道显示,加速器质谱技术(AMS)在定量研究微量毒物与生物大分子加合方面具有广泛的应用前景.例如,他们首次成功地用加速器质谱技术,探测研究了致癌物2-氨基-3,8-二甲基咪唑-(4,5-f)喹喔啉(MeIQx)与DNA的共价结合.其探测灵敏度极高,可达每10~(11)～10~(12)核苷酸一个加合.近年来,AMS在生物医学领域的应用已引起人们的广泛关注.我们可以预言,近年内此类研究将迅速增加,特别是在环境剂量水平的药物和化学物质的基因毒性及危险性评估方面.
Since 1990, many reports from the National Laboratory of Lawrence Livermore in the United States have shown that Accelerator Mass Spectrometry (AMS) has a wide range of applications in the quantitative study of additive addition of trace poisons to biological macromolecules, for example, they were the first to successfully use accelerator mass spectrometry , The covalent bonding of DNA with carcinogenic 2-amino-3,8-dimethylimidazolium- (4,5-f) quinoxaline (MeIQx) has been probed and its detection sensitivity is very high up to 10 ~ (11) ~ 10 ~ (12) nucleotides.In recent years, the application of AMS in the field of biomedicine has attracted people’s attention.We can predict that in recent years, such research will rapidly increase, especially in the environment Dose levels of genotoxicity and risk assessment of drugs and chemicals.