由于某些高度易感单位的乙型肝炎发病率很高,如1975年法国血液透析单位的工作人员和病人中,乙型肝炎的发病率高达40%,作者曾用高纯度的乙型肝炎疫苗对未曾暴露于乙型肝炎的人进行了接种。结果表明,接种后不出现感染性标志(血清转氨酶、HBsAg及抗-HBc持续阴性);免疫原性也好,(98%的接种者出现抗-HBs抗体)。对接种者逐月观察生物学及临床情况,也没有发现因疫苗接种而引起的并发症及自身免 Because of the high incidence of hepatitis B in some highly-susceptible units, hepatitis B incidence was as high as 40% of staff and patients in French hemodialysis units in 1975. The authors used high-purity hepatitis B vaccine People who have not been exposed to hepatitis B have been vaccinated. The results showed no signs of infectivity (serum transaminase, HBsAg and anti-HBc persistent negatives) after vaccination; immunogenicity was also good (98% of vaccinates developed anti-HBs antibodies). Vaccinations observed monthly biological and clinical conditions, but also did not find the complications caused by the vaccination and self-exempt