论文部分内容阅读
目的:观察甘精胰岛素联合那格列奈强化治疗初发2型糖尿病的疗效。方法:采取对照的方法选取初次诊断为HbA1c>8.0%的2型糖尿病患者123例,每天为患者进行一次皮下注射甘精胰岛素,同时联合那格列奈进行治疗。疗程为3个月,对比治疗前后患者的糖化血红蛋白(HbA1c)、空腹血糖(FBG)、用餐后2小时的血糖(2hPG)、空腹C肽、用餐后2小时的C肽、空腹时的血清胰岛素(FINS)、用餐后2小时的血清胰岛素(2hINS)以及不良情况的反应。结果:治疗后患者的糖化血红蛋白(HbA1c)、空腹血糖(FBG)以及用餐后2小时的血糖(2hPG)的指数均明显下降,空腹时C肽水平变化不明显,空腹血清胰岛素指数明显上升,用餐后2小时C肽和血清胰岛素(2hINS)指数明显上升。结论:甘精胰岛素联合那格列奈强化治疗对初发2型糖尿病疗效显著。
Objective: To observe the efficacy of insulin glargine combined with nateglinide in the treatment of newly diagnosed type 2 diabetes. Methods: A controlled trial was conducted to select 123 patients with type 2 diabetes who were initially diagnosed as having HbA1c> 8.0%. Patients were given insulin glargine subcutaneously once a day for the treatment of nateglinide. The course of treatment was 3 months. The levels of HbA1c, FBG, 2hPG, fasting C-peptide, C-peptide 2h after meal, fasting serum insulin (FINS), serum insulin 2 hours after meal (2 hINS), and adverse reactions. Results: After treatment, HbA1c, fasting blood glucose (FBG) and blood glucose (2hPG) index of 2 hours after meal were significantly decreased, fasting serum C-peptide levels did not change significantly, fasting serum insulin index increased significantly, meal Two hours after C peptide and serum insulin (2hINS) index increased significantly. CONCLUSIONS: Glargine and nateglinide are effective in treating type 2 diabetes mellitus.