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目的:观察活血灵干预创伤诱导的SD大鼠跟腱异位骨化的效应。方法:90只SD大鼠行右侧跟腱切断术,分为活血灵组、布洛芬组和空白对照组,每组30只,分别于术后第5、10周行X线和组织学检查。结果:5周时组织学检查发现有软骨及骨形成,其中空白对照组异位骨化发生率为66.7%,布洛芬组和活血灵组异位骨化发生率分另为26.7%和20.0%,与空白对照组比较,差异均有显著性意义(P<0.05);布洛芬组和活血灵组比较,差异无显著性意义(P>0.05);10周后所有空白对照组大鼠均出现异位骨化,布洛芬组和活血灵组异位骨化发生率分别为53.3%和46.7%,与空白对照组比较,差异均有非常显著性意义(P<0.01);布洛芬组和活血灵组比较,差异无显著性意义(P>0.05)。结论:活血灵能有效干预创伤诱导的SD大鼠跟腱异位骨化。
OBJECTIVE: To observe the effect of Huoxueling on wound-induced ectopic ossification of Achilles tendon in SD rats. Methods: Thirty-nine SD rats underwent right heel transection and were divided into Huoxueling group, ibuprofen group and blank control group. Thirty rats in each group were performed X-ray and histology at the 5th and 10th week after operation respectively. an examination. RESULTS: At 5 weeks, cartilage and bone formation were found on histological examination. The incidence of heterotopic ossification in the control group was 66.7%, and the incidence of heterotopic ossification in the ibuprofen group and Huoxueling group was 26.7% and 20.0, respectively. %, compared with the blank control group, the difference was significant (P<0.05); there was no significant difference between the ibuprofen group and the Huoxueling group (P>0.05); all the blank control group rats after 10 weeks Heterotopic ossification occurred in all patients. The incidence of heterotopic ossification in the ibuprofen group and Huoxueling group was 53.3% and 46.7%, respectively. Compared with the blank control group, the differences were significant (P<0.01); Buluo There was no significant difference between the Fen group and Huoxueling group (P>0.05). Conclusion: Huoxueling can effectively interfere with traumatic induced Heterotopic ossification of SD rats.