神经母细胞瘤 (neuroblastoma ,简称NB)是来源于节后交感神经系统的胚胎性恶性肿瘤 ,绝大多数来源于肾上腺 ,在小儿恶性肿瘤中居第三位 ,占所有小儿恶性肿瘤病死率的15 % [1 ] 。96 %的患儿发病年龄在 10岁以前[2 ] 。神经母细胞瘤在临床上具有多样性 ,恶性度高 ,预后差的特点 Neuroblastoma (NB) is an embryonal malignant tumor originated from the sympathetic postganglionic sympathetic system, the vast majority of which originate from the adrenal gland. It ranks third in pediatric malignancies and accounts for 15% of all pediatric malignancies. [1 ] . 96% of children age at onset of 10 years of age [2]. Neuroblastoma is clinically diverse, with high malignancy and poor prognosis