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目的 :观察干扰素α 2b的不良反应及其防治措施。方法 :5 2例慢性乙型肝炎患者 ,干扰素α 2b开始 2周 2 0 0万uimqd ,第 3周后为 2 0 0万uim每周 3次 ,3个月后观察干扰素α 2b的不良反应。 结果 :5 2例患者绝大多数只有发热等流感样症状及轻度头痛等症状 ,没有危及生命的严重不良反应 ,但有 4例患者因为剧烈头痛 ,白细胞明显减少及全身皮疹不能耐受而停止治疗。结论 :干扰素α 2b引起的不良反应以轻微的较多 ,但发生率很高。
Objective: To observe the adverse reactions of interferon α 2b and its prevention and treatment. METHODS: Fifty-two patients with chronic hepatitis B were treated with interferon alfa 2b 20 million uimqd for 2 weeks, 20 million uim three times per week after 3 weeks, and 3 months after treatment for interferon alpha 2b reaction. Results: The overwhelming majority of 52 patients had only fever-like flu-like symptoms and mild headache with no serious life-threatening adverse reactions, but 4 patients stopped because of severe headache, markedly reduced white blood cells and general inability to tolerate rashes treatment. Conclusions: The adverse reactions caused by interferon alfa 2b are slightly more severe, but the incidence is high.