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目的：观察奥美拉唑对肝硬化门静脉高压性胃粘膜病变的疗效及对此类上消化道出血的预防作用。方法：对５２例患者分别予以奥美拉唑及空白对照，监测服药后胃内２４ｈｐＨ值变化。结果：３０例患者服药后２４ｈｐＨ值明显升高，与空白对照相差显著（Ｐ＜０．０１）。奥美拉唑组服药后，ｐＨ＞４的总时间和平均ｐＨ值及中位ｐＨ值均明显高于对照组。晨间及晚间组口服奥美拉唑后差异不显著。结论：奥美拉唑对门静脉高压性胃粘膜病变具有预防及治疗效果。
Objective: To observe the curative effect of omeprazole on portal hypertensive gastropathy in cirrhotics and its preventive effect on such upper gastrointestinal hemorrhage. Methods: Fifty-two patients were treated with omeprazole and blank control respectively, and the changes of gastric intrahepatic 24hpH value were monitored. Results: The values of 24hpH in 30 patients were significantly higher than those in blank control group (P <0.01). Omeprazole group after taking medicine, pH> 4 total time and average pH and median pH were significantly higher than the control group. There was no significant difference between morning and evening oral omeprazole group. Conclusion: Omeprazole has preventive and therapeutic effects on portal hypertensive gastric mucosal lesions.