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目的:观察不同高温状态对大鼠血液流变学状态的影响。方法:将50只SD大鼠随机分为对照组和实验A、B、C、D组,每组10只。实验组分别采用39℃、41℃、41.8℃和43℃并持续两小时。分别检测各组全血还原粘度、血球压积、血沉、纤维蛋白原、红细胞变形指数和红细胞聚集指数等。结果:在不同温度下,各组血沉、纤维蛋白原无显著改变。全血还原粘度、血球压积在41.8℃以下时较对照组显著降低,但温度达到43℃时,全血还原粘度和血球压积显著升高。红细胞变形指数在41.8℃及以下时较对照组显著升高,但在温度为43℃时,红细胞变形指数显著降低。红细胞聚集指数的变化与红细胞变形指数相反。结论:不同的高温状态可对大鼠血液流变学产生不同的影响。
Objective: To observe the effects of different high temperature on the hemorheology in rats. Methods: 50 SD rats were randomly divided into control group and experimental groups A, B, C and D, with 10 rats in each group. The experimental groups were 39 ℃, 41 ℃, 41.8 ℃ and 43 ℃ respectively for two hours. The reduction of whole blood viscosity, hematocrit, erythrocyte sedimentation rate, fibrinogen, erythrocyte deformability index and erythrocyte aggregation index were detected in each group. Results: At different temperatures, there was no significant change in erythrocyte sedimentation rate and fibrinogen in each group. Whole blood reduced viscosity, hematocrit below 41.8 ℃ significantly lower than the control group, but the temperature reaches 43 ℃, the whole blood reduced viscosity and hematocrit were significantly increased. Erythrocyte deformation index at 41.8 ℃ and below significantly higher than the control group, but at a temperature of 43 ℃, erythrocyte deformation index decreased significantly. Changes in erythrocyte aggregation index and red blood cell deformity index opposite. CONCLUSIONS: Different hyperthermic conditions can have different effects on hemorheology in rats.