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本文对青海省喜马拉雅旱獭鼠疫自然疫源地内的383株鼠疫菌的毒力测定结果进行了分析。有373株属于强毒鼠疫菌,7株为中等毒力菌,3株为自然界分离的弱毒鼠疫菌。于同一地区不同流行年代、不同宿主分离的鼠疫菌毒力无明显差异,青藏高原型菌株毒力比祁连山型菌株毒力强。缺失Pgm、VW因子的菌株大多毒力减弱,但有的也保持了较强毒力。另有12株经过长期人工培养基传代保存的菌株毒力明显降低。
In this paper, the virulence of 383 strains of Yersinia pestis in the natural foci of Hamster plague in Qinghai Province was analyzed. There are 373 strains of virulent Yersinia pestis, 7 strains of which are moderately virulent and 3 strains of attenuated Yersinia pestis isolated from nature. There was no significant difference in the virulence of plague isolates from different hosts in different popularization age in the same area, and the virulence of Tibetan Plateau strains was stronger than that of Qilian isolates. Most strains lacking Pgm and VW factors weakened, but some also maintained strong virulence. Another 12 strains of strains that had been passaged for a long time under artificial culture medium were significantly less virulent.