许多不育研究中心在进行IVF前,以周期第3天FSH水平或克罗米芬(CC)刺激试验评估卵巢储备。虽然两者的预测结果较女方年龄准确,但FSH水平有显著的周期间波动,因而价值有限。FSH水平和CC刺激后反应(即第10天FSH水平)的联合测定可提高检测卵巢储备衰退崔度的能力。CC刺激试验的生理基础是通过CC拮抗雌激素而发挥作用。在CC作用下,抑制FSH的唯一机制可能是通过卵巢抑制素的作用,包括抑制素A及抑制素B,它们均为颗粒细胞(GC)的产物,前者主要在黄体期分 Many infertility centers evaluate ovarian reserve by FSH level on day 3 of the cycle or clomiphene citrate (CC) stimulation test prior to IVF. Although the predictions of both are more accurate than those of women, FSH levels fluctuate significantly over the period and therefore have limited value. The combined measurement of FSH levels and response to CC stimulation (ie day 10 FSH levels) improves the ability to detect Cui degree of ovarian reserve decline. The physiological basis of the CC stimulation test is to act by antagonizing estrogen by CC. The only mechanism by which CCI inhibits FSH may be through the action of ovarian inhibin, including inhibin A and inhibin B, all of which are products of granulosa cells (GC), the former mainly in the luteal phase