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目的 :检测胃腺癌组织中胀亡与TSP - 1。方法 :采用免疫组化SP法检测 4 5例胃腺癌组织中TSP - 1的表达 ,并与正常对照组进行比较 ,利用透射电镜技术观察其中肿瘤细胞的胀亡情况。结果 :①TSP - 1在胃腺癌组织中阳性表达率为 4 6 .6 7% ,在正常胃粘膜中未见表达 ,差异有显著性 ;②胃腺癌组织中发现有不同时期的胀亡细胞 ,胀亡指数 (OI)在TSP - 1阳性组、阴性组分别为 (2 .78± 0 .96 )、(1 .0 5± 0 .34) ,2组间差异有统计学意义 (P <0 .0 5 ) ;③OI、TSP - 1的阳性表达率在有淋巴结转移组高于无淋巴结转移组 (P <0 .0 5 ) ;④TSP - 1及OI与胃癌的大体分型、组织学类型、肿瘤大小、肿瘤部位及患者性别、年龄无关。结论 :胃腺癌组织中TSP - 1可抑制肿瘤血管形成 ,从而抑制肿瘤的侵袭转移 ,加速胀亡的形成
Objective: To detect the expansion and contraction of TSP - 1 in gastric adenocarcinoma. Methods: The expression of TSP - 1 in 45 cases of gastric adenocarcinoma was detected by immunohistochemical SP method. The expression of TSP - 1 in gastric adenocarcinoma was detected by transmission electron microscopy. Results: ① The positive expression rate of TSP - 1 in gastric adenocarcinoma was 46.76%, which was not found in normal gastric mucosa, and the difference was significant. ②The cells of peritoneal exudate were found in gastric adenocarcinoma with different stages The index of death (OI) in TSP - 1 positive group and negative group were (2.78 ± 0.96) and (1.05 ± 0.34), respectively. The difference between the two groups was statistically significant (P <0. The positive expression rate of OI and TSP - 1 was higher in patients with lymph node metastasis than those without lymph node metastasis (P <0.05). (4) The general classification of TSP - 1 and OI and gastric cancer, histological type, Size, tumor location and patient gender, age has nothing to do. Conclusion: TSP - 1 can inhibit tumor angiogenesis in gastric adenocarcinoma and thus inhibit the invasion and metastasis of tumor and accelerate the formation of