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目的对比分析全胃切除术与近侧胃大部切除术治疗贲门腺癌的临床疗效。方法回顾性分析2008年8月—2010年2月间在本院治疗的106例贲门腺癌患者的临床记录资料,将其随机分为两组。治疗组53例,行全胃切除术;对照组53例,行近侧胃大部切除术。治疗后比较两组疗效。结果治疗后,治疗组的总有效率为90.57%,高于对照组的75.47%,差异有统计学意义(P<0.05)。治疗组的3年生存率、5年生存率均高于对照组均有统计学意义(均P<0.05)。治疗组的清蛋白、总蛋白、血红蛋白水平虽略高于对照组,差异均无统计学意义(均P>0.05)。治疗组的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论全胃切除术治疗贲门腺癌的临床疗效显著,值得临床推广应用。
Objective To compare the clinical effects of total gastrectomy and proximal gastrectomy in the treatment of gastric cardia adenocarcinoma. Methods The clinical records of 106 patients with GCA treated in our hospital from August 2008 to February 2010 were retrospectively analyzed. They were randomly divided into two groups. In the treatment group, 53 cases underwent total gastrectomy. In the control group, 53 cases underwent subtotal gastrectomy. After treatment, the two groups were compared. Results After treatment, the total effective rate of the treatment group was 90.57%, which was higher than that of the control group (75.47%), the difference was statistically significant (P <0.05). The 3-year survival rate and 5-year survival rate of the treatment group were significantly higher than those of the control group (all P <0.05). Although albumin, total protein and hemoglobin in the treatment group were slightly higher than those in the control group, there was no significant difference (all P> 0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Total gastrectomy for the treatment of gastric cardia adenocarcinoma has significant clinical efficacy and is worthy of clinical application.