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目的 应用扩散张量成像(DTI)技术研究纹状体内囊梗死(SCI)患者急性期大脑脚扩散改变情况,分析其与上肢运动功能损害的关系.方法 选择首次急性起病,有单侧上肢运动功能损害的SCI患者18例,于发病后2周行DTI扫描,测量两侧大脑脚的各向异性分数(FA)、平均扩散率(MD)值,计算两侧FA的不对称指数(AI),对AI和受累上肢的FM功能评分进行相关分析.结果 发病后2周时患侧大脑脚FA值较健侧降低,两侧MD值无显著差异,AI与受累上肢的FM评分呈显著负相关(r=-0.91,P＜0.01).结论 DTI可以早期检测到SCI患者大脑脚的扩散变化,该部位锥体束的完整性与受累上肢的运动功能关系密切,DTI检查可以为SCI的早期临床评估提供量化的影像学参考.“,”Objective Using diffusion tensor imaging (DTI) to study the diffusion changes in cerebral peduncle in patients with acute striatocapsular infarction complicated by upper limb motor functional damage,and to discuss the relationship between the striatocapsular infarction and the upper limb motor functional damage.Methods A total of 18 patients with unilateral upper limb motor functional damage after the first onset of acute striatocapsular infarction were enrolled in this study.DTI scanning was performed in all patients within two weeks after the onset of the disease.The fractional anisotropy (FA) and the mean diffusivity (MD) of bilateral cerebral peduncles were measured,and the asymmetry index (AI) of bilateral FA was calculated.The correlation between AI and the involved upper limb motor function scores was evaluated.Results Two weeks after the onset of the disease,the FA value of cerebral peduncle at affected side was significantly lower than that at the unaffected side,and no significant difference in the MD values existed between the two side.AI carried a statistically significant negative relationship with the involved upper limb motor function scores (r =-0.91,P ＜ 0.01).Conclusion DTI can detect the early diffusion changes in cerebral peduncle after striatocapsular infarction.The integrity of pyramidal tract in cerebral peduncle is closely correlated with the motor function of involved upper limb.DTI can provide quantitative imaging reference for clinical assessment of striatocapsular infarction.