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为了探讨血清肌钙蛋白Ｔ浓度对急性心肌梗塞静脉溶栓治疗疗效的判定价值。选择接受静脉溶栓治疗的急性心肌梗塞患者９２例，以酶联免疫吸附测定法测定血清肌钙蛋白Ｔ浓度，比较其中６５例梗塞相关血管再通组与２７例未通组之间的血清肌钙蛋白Ｔ变化特点。结果发现：（１）大部分急性心肌梗塞患者于发病后第４～８ｈ血清肌钙蛋白Ｔ开始升高，且再通组比未通组有提前升高的趋势（但Ｐ＞０．０５）；（２）再通组比未通组，发病后第一峰值时间提前（１７．８±１２．５ｈ比２８．６±１６．０ｈ，Ｐ＜０．００１）；且第一峰值水平有升高趋势（３４．６±３９．１μｇ／Ｌ比２７．０±３１．６μｇ／Ｌ，Ｐ＞０．０５）；（３）对急性心肌梗塞的梗塞相关血管再通价值之敏感性、特异性及准确性，分别在肌钙蛋白Ｔ峰值时间≤１２ｈ为５５．４％、８５．２％及６４．１％；在≤１６ｈ为７６．９％、７７．８％及７７．２％，比ＣＫ－ＭＢ≤１４ｈ的６１；５％、７４．１％及６５．２％有更好的应用价值。提示肌钙蛋白Ｔ对于急性心肌梗塞的梗塞相关血管再通有一定判断价值，尤其以第一峰时间≤１６ｈ的敏感性较ＣＫ－ＭＢ为高。
In order to investigate the value of serum troponin T in evaluating the curative effect of intravenous thrombolysis in acute myocardial infarction. Ninety-two patients with acute myocardial infarction who received intravenous thrombolysis were enrolled in this study. Serum troponin T concentration was measured by enzyme-linked immunosorbent assay (ELISA), and serum myosin T was compared between 65 infarct-related revascularization groups and 27 unrelated patients Features of calmodulin T changes. The results showed that: (1) Serum troponin T began to increase in the majority of acute myocardial infarction patients from the 4th to 8th hour after onset, and there was a trend of early increase in the recanalization group (P> 0.05) ; (2) The recanalization group was earlier than the non-recanalization group, the first peak time after onset was earlier (17.8 ± 12.5h vs 28.6 ± 16.0h, P <0.001); and the first peak level increased (34.6 ± 39.1μg / L vs 27.0 ± 31.6μg / L, P> 0.05). (3) The sensitivity and specificity of the value of infarct related revascularization in acute myocardial infarction And accuracy were 55.4%, 85.2% and 64.1% respectively at peak time of troponin T ≤12h, 76.9%, 77.8% and 77.2% at ≤16h CK-MB≤14h 61; 5%, 74.1% and 65.2% have better application value. It is suggested that troponin T has some diagnostic value for infarct-related revascularization in acute myocardial infarction. In particular, the sensitivity of first peak time ≤16h is higher than that of CK-MB.