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目的琥珀酸氢化可的松与丙球治疗儿童难治性支原体肺炎(RMPP)的临床疗效比较。方法将符合RMPP诊断的60例患儿随机分为两组，在阿奇霉素序贯治疗联合三代头孢菌素治疗基础上，治疗1组加用琥珀酸氢化可的松治疗，治疗2组加用丙种球蛋白治疗，对比两组治疗显效率、总有效率及热退时间、咳嗽缓解时间和胸部影像学恢复时间。结果治疗10d后，治疗1组(激素组)总有效率96.7%，显效率66.7%，治疗2组(丙球组)总有效率86.7%，显效率36.7%，两组显效率比较有显著差异，总有效率比较无显著差异。两组热退时间、咳嗽缓解时间和胸部影像学恢复时间比较，率激素组均优于丙球组，两组比较有显著差异(<0.05)。结论琥珀酸氢化可的松和丙球在难治性支原体肺炎的治疗中均有明确疗效，但使用琥珀酸氢化可的松辅助治疗RMPP可明显缩短患儿的发热时间、咳嗽缓解时间及影像学改变消退时间。“,”Objective Hydrocortisone succinate and immunoglobulin in treatment of children with refractory Mycoplasma pneumoniae pneumonia (RMPP) clinical curative ef ect comparison. Methods The children were randomly divided into 60 cases of diagnosed RMPP into 2 groups, The two groups were given Azithromycin Sequential Therapy Combined with the three generation cephalosporin treatment. Treatment of 1 group was treated with hydrocortisone succinate treatment, and the treatment of the 2 groups combined with gamma globulin in the treatment of.Comparing the two groups of the treatment ef iciency, the duration of fever, cough relief time and radiological recovery time.Results Treatment group 1 (glucocorticoid group) the total ef iciency of 96.7%, Significant ef iciency of 66.7%, Treatment group 2 (immunoglobulin group) the total ef iciency of 86.7%, Significant ef iciency 36.7%, Two groups of comparisons show the Significant ef iciency has the Significant dif erence, the total ef iciency of no Significant dif erence. The duration of fever, cough relief time and radiological recovery time in hormone treatment group, was significantly shorter than immunoglobulin group, two groups had significant dif erence ( <0.05).Conclusion Hydrocortisone succinate and immunoglobulin were ef ective in the treatment of children with refractory Mycoplasma pneumoniae pneumonia. Compared with the combined with gamma globulin, combined with hydrocortisone succinate RMPP adjuvant therapy can significantly shorten the time of children with fever, cough relief time and radiological recovery time.