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目的:探讨转移抑制基因nm23-H1的表达与胆管细胞癌临床病理及预后的关系。方法:25例胆管细胞癌标本,制成石蜡切片,采用免疫组织化学ABC法染色。结果:11例（40％）为阳性表达,14例（56％）为阴性表达。nm23-H1的表达与肿瘤大小、肿瘤部位、侵及浆膜、肝外转移、肿瘤破裂、淋巴结转移、侵及门静脉、分化程度和生存率无关。术后2年内的复发率nm23-H1阴性表达例（71.4％）高于阳性表达例（45.5％）,但这一区别没有显著性差异（P>0.05）。结论:nm23-H1在胆管细胞病中所起的作用不同。nm23-H1的表达对胆管细胞癌不具有预后指示作用。
Objective: To investigate the relationship between the expression of metastasis suppressor gene nm23-H1 and the clinicopathology and prognosis of cholangiocarcinoma. Methods: Twenty-five cholangiocarcinoma specimens were made into paraffin sections and stained with immunohistochemical ABC method. Results: 11 cases (40%) were positive and 14 cases (56%) were negative. The expression of nm23-H1 was not associated with tumor size, tumor site, serosal invasion, extrahepatic metastasis, tumor rupture, lymph node metastasis, invasion of portal vein, degree of differentiation and survival rate. The recurrence rate of nm23-H1 negative cases (71.4%) was higher than that of positive cases (45.5%) within 2 years after operation, but there was no significant difference (P> 0.05). Conclusion: nm23-H1 plays a different role in cholangiocarcinoma. The expression of nm23-H1 does not have prognostic significance for cholangiocarcinoma.