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为探讨乳腺分叶状瘤的组织来源,应用免疫组织化学SP法对53例乳腺分叶状瘤进行了波形蛋白(Vim)、平滑肌肌动蛋白(Act)、S-100蛋白、溶菌酶(Lys)、结蛋白(Des)进行了观察。结果发现,53例分叶状瘤、5例纤维腺瘤中Vim标记均为阳性;53例分叶状瘤中Act、S-100、Lys、Des阳性分别为34、13、3、1例。免疫组化标记对于鉴别肿瘤的良、恶性有意义,发现34例分叶状瘤具有肌纤维性质,其中11例组织发生与肌上皮细胞有关。上述结果表明,分叶状瘤实质上是一种起源于管周多能性间叶细胞,具有向腺上皮、平滑肌和纤维组织等多向分化倾向的恶性肿瘤。
To investigate the tissue origin of breast lobulated tumors, Vim, Actin, S-100 protein, Lysozyme (Lys) were performed on 53 cases of breast phyllodes tumor by immunohistochemical SP method. ), Des protein (Des) was observed. The results showed that 53 cases of lobulated tumors and 5 cases of fibroadenomas were all positive for Vim; 53 cases of lobulated tumors were positive for Act, S-100, Lys, and Des respectively 34, 13, 3, and 1 cases. Immunohistochemical markers were useful for the differentiation of benign and malignant tumors. 34 lobulated tumors were found to have muscle fiber properties, 11 of which were associated with myoepithelial cells. The above results indicate that the phyllodes tumor is essentially a pluripotent mesenchymal cell originating from the perivascular area, and has a multi-directional differentiation of malignant tumors such as glandular epithelium, smooth muscle and fibrous tissue.