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自25年前首次介绍经皮肤取肾脏活组织检查以来,它已成为日常的诊断方法,从而对肾脏疾病的组织病变、发病机制、自然演变、治疗指证、疗效估价、预后知识等有所阐明,它也为晚期肾衰患者寻求透析或肾脏移植治疗提供依据。作者对28例到1973年止为期4年不可逆性的晚期肾衰患者的肾活检结果进行了回顾复习。病例选择 1.本组均属晚期肾衰患者;2.多数都有尿毒症症状,每例或需维持性透析、或肾移植、或已死亡;3.各例均于血液透析或腹膜透析24小时后进行肾活检;4.凝血酶原时间、部分凝血活酶时间、血小板、出凝血时间等凝血参数均属正常。诊断方法所有活检标本都经光学及电子显微镜和免疫荧光检查,诊断由上述专家会同临床医生商议决定。
It has become a routine diagnostic method since it was introduced for the first time 25 years ago and has been elucidated on the histopathology, pathogenesis, natural evolution, therapeutic evidence, therapeutic evaluation, and prognostic knowledge of kidney disease. It also provides a basis for dialysis or kidney transplantation in patients with advanced renal failure. The authors reviewed the results of renal biopsy in 28 patients with advanced renal failure who had been unrelated for 4 years until 1973. Case selection 1. This group are patients with advanced renal failure; 2. Most have uremic symptoms, each case or need for maintenance dialysis, or kidney transplantation, or have died; 3. All cases were hemodialysis or peritoneal dialysis Hours after the renal biopsy; 4. prothrombin time, partial thromboplastin time, platelets, clotting time clotting parameters are normal. Diagnostic Methods All biopsy specimens were examined by light and electron microscopy and immunofluorescence and diagnosed by the above-mentioned experts in consultation with the clinician.