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目的:目前,关于冠心病的临床病程已积累了大量资料;然而,关于冠状动脉病变的进展或消退情况及其与临床事件的相互关系的资料却很有限,作者对此进行了探讨。材料和方法:对230例平均年龄为53.2岁患者进行了为期3年的前瞻性研究。病人均为轻度或中度冠脉狭窄患者,定期重复冠状动脉造影检查以评价冠状动脉病变的进展及消退情况。采用电子计算机辅助的冠状动脉造影分析系统测量了最小狭窄直径,各节段直径及以百分比表示的狭窄程度,病变进展定义为在原有狭窄的基础上,狭窄加重20%以上(包括完全闭塞),或在无狭窄的冠脉节段上出现≥20%的新狭窄病变或完全闭塞。在第1次冠脉造影时,四支主要冠脉中共有838处≥20%的狭窄节段
OBJECTIVE: Currently, there is a wealth of data available on the clinical course of coronary heart disease; however, there is limited information on the progression or regression of coronary artery disease and its relationship to clinical events, and the authors discussed this. Materials and Methods: A prospective 3-year study of 230 patients with a mean age of 53.2 years was conducted. Patients were mild or moderate coronary stenosis patients, regular coronary angiography to assess the progress of coronary lesions and regression. The computer-assisted coronary angiography system was used to measure the minimum stenosis diameter, the diameter of each segment, and the degree of stenosis as a percentage. The progression of the lesion was defined as a 20% increase in stenosis (including complete occlusion) on the basis of the original stenosis, Or> 20% new stenosis or complete occlusion in stenotic coronary segments. At the first coronary angiography, there were 838 ≥20% stenosis segments in the four major coronary arteries