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从止咳、祛痰、抗炎、免疫等 4方面对咳喘灵涂膜剂进行了部分药效学实验研究 ,结果表明该制剂能够显著延长浓氨水引起的小鼠咳嗽反应的潜伏期 ,提高小鼠呼吸道酚红的排泌量 ,抑制二甲苯所致的小鼠耳廓肿胀 ,提高小鼠血清溶血素抗体水平及促进DNCB所致的小鼠迟发性过敏反应。实验结果提示出该制剂具有止咳、化痰 ,提高特异性免疫功能和抗炎的作用 ,为其临床的推广应用提供了一定的药理学依据。
Some pharmacodynamic experiments were conducted on cough phlegm, anti-inflammation, and immunity from four aspects. The results showed that the preparation can significantly prolong the incubation period of mice cough response caused by concentrated ammonia, and increase the mice’s The amount of phenol red excretion in the respiratory tract inhibited swelling in the ear of mice caused by xylene, increased serum hemolysin antibody levels in mice, and promoted delayed allergic reactions in mice caused by DNCB. The experimental results suggest that the preparation has antitussive and phlegm-removing effects, improves specific immune function and anti-inflammatory effects, and provides certain pharmacological basis for its clinical application.