脑梗死的病死率和致残率均很高,给社会和家庭带来了巨大负担。但目前在临床上无论是药物治疗还是外科手术治疗效果均不理想。最近的研究发现,骨髓间充质干细胞具有多向分化潜能,并能够分泌一系列神经营养因子,对中枢神经系统具有重要的神经功能保护作用,对脑梗死的治疗具有广阔的前景。现就骨髓间充质干细胞治疗脑梗死的应用研究进展及其治疗作用机制进行了综述。 The mortality and morbidity of cerebral infarction are both high, putting a huge burden on society and families. However, no clinical or surgical treatment is satisfactory. Recent studies have found that BMSCs have multi-directional differentiation potential and can secrete a series of neurotrophic factors, which have important neuroprotective effects on the central nervous system and have broad prospects for the treatment of cerebral infarction. Now on the application of bone marrow mesenchymal stem cells in the treatment of cerebral infarction research progress and its therapeutic mechanism are reviewed.