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目的:探讨白川胶囊对自发性高血压大鼠(SHR)血压、左心肥厚(LVH)及血浆中血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)含量的变化的影响。方法:选取自发性高血压大鼠和京都种Wistar大鼠(WKY)分别作为模型对照和正常对照,用白川胶囊进行为期3个月的干预,期间监测血压变化,卡托普利作为阳性对照药。大鼠处死后称量左心室质量并计算左心肥厚指数,对左心室进行病理生态学观察,用放射免疫法测定血浆中AngⅡ和ALD。结果:白川胶囊在平稳降压的同时可以抑制左心肥厚,并且显著下调大鼠血浆中AngⅡ和ALD的水平。结论:白川胶囊对SHR大鼠的左心肥厚及血浆中AngⅡ和ALD水平有一定的抑制作用。
Objective: To investigate the effect of Baichuan capsule on blood pressure, left ventricular hypertrophy (LVH), plasma levels of angiotensin Ⅱ (Ang Ⅱ) and aldosterone (ALD) in spontaneously hypertensive rats (SHR) Methods: The spontaneous hypertensive rats and Kyoto Wistar rats (WKY) were selected as the model control and normal control. The patients were treated with Shirakawa Capsule for 3 months. Blood pressure was monitored during the study. Captopril was used as a positive control . The left ventricular mass was measured and the left ventricular hypertrophy index was calculated after sacrifice. The left ventricle was observed for pathophysiology and the plasma Ang Ⅱ and ALD were measured by radioimmunoassay. Results: Shirakawa Capsule can depress left ventricular hypertrophy while stabilizing blood pressure and down-regulate the levels of AngⅡ and ALD in rats plasma. Conclusion: Baichuan can inhibit left ventricular hypertrophy and plasma Ang Ⅱ and ALD levels in SHR rats.