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目的：探讨内皮素（ET）与肝内胆汁淤积症（ICP）的关系。方法：采用放射免疫法测定27例ICP妇女（ICP组）外周血中ET的含量，同期住院的正常晚期妊娠妇女25例（正常妊娠组）作为对照。结果：ICP组妇女血清ET含量较正常妊娠组明显增高（P＜0．05）；ICP组平均孕龄较正常妊娠组缩短，平均新生儿体重显著低于正常妊娠组。结论：ET参与胎盘的病理变化，与ICP妇女并发的胎儿宫内发育迟缓、早产、胎儿宫内窘迫等有一定关系。
Objective: To investigate the relationship between endothelin (ET) and intrahepatic cholestasis (ICP). Methods: The contents of ET in peripheral blood of 27 ICP patients (ICP group) were determined by radioimmunoassay. Twenty-five normal pregnant women (normal pregnancy group) were hospitalized in the same period as control group. Results: The levels of serum ET in ICP group were significantly higher than those in normal pregnancy group (P <0.05). The average gestational age in ICP group was shorter than that in normal pregnancy group, and the mean neonatal weight was significantly lower than that in normal pregnancy group. Conclusion: ET is involved in the pathological changes of the placenta, which is related to ICP intrauterine growth retardation, premature labor and fetal distress.