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采用跳台法研究药物对小鼠的学习记忆获得过程的影响，ｉｐ绞股蓝皂甙ＸＬⅢ（ＧｙｎＸＬⅢ）１５ｍｇ／ｋｇ对小鼠的学习记忆获得过程无影响（Ｐ＞０．０５），３０ｍｇ／ｋｇ可增强小鼠的学习记忆获得过程（Ｐ＜０．０５），东莨菪碱０．３ｍｇ／ｋｇ造成小鼠出现明显的记忆障碍（Ｐ＜０．０１）。ＧｙｎＸＬⅢ３０ｍｇ／ｋｇ显著提高脑内Ｇｌｕ水平（Ｐ＜０．０５），明显降低ＧＡＢＡ水平（Ｐ＜０．０５）；东莨菪碱（Ｓｃｏｐ）０．３ｍｇ／ｋｇ的结果相反，显著降低Ｇｌｕ水平（Ｐ＜０．０１），提高ＧＡＢＡ水平（Ｐ＜０．０５）；预先予ＧｙｎＸＬⅢ３０ｍｇ／ｋｇ，５ｍｉｎ后再予东莨菪碱０．３ｍｇ／ｋｇ。结果显示，ＧｙｎＸＬⅢ扭转Ｓｃｏｐ升高ＧＡＢＡ的作用，使之显著下降（Ｐ＜０．０５），对Ｇｌｕ的影响不大（Ｐ＞０．０５）。
The effect of drug on mouse learning and memory was studied by the method of step-down. ip gypsophila saponin XLIII (GynXLIII) 15mg/kg had no effect on the learning and memory of mice (P>0.05), 30mg/kg could enhance small The acquisition of learning and memory in mice (P<0.05), scopolamine 0.3 mg/kg caused significant memory impairment in mice (P<0.01). GynXLIII30mg/kg significantly increased the level of Glu in the brain (P<0.05), significantly reduced the level of GABA (P<0.05); the result of scopolamine 0.3mg/kg was the opposite and significantly decreased the level of Glu (P<0). .01) Increased GABA levels (P<0.05); GynXLIII was pretreated with 30 mg/kg, 5 min later and scopolamine 0.3 mg/kg. The results showed that GynXLIII reversed the action of Scop to increase GABA, which significantly decreased (P<0.05), and had little effect on Glu (P>0.05).