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1、本实验检查了一次经腹腔注入每公斤体重1.0、0.5……0.001毫克硝酸铀酰溶液经3、7、14、和21天后大白鼠肾脏的组织学变化。 2、和致死剂量铀中毒一样,小剂量铀中毒后肾上皮细胞损害也主要位于迷路尖端的近曲管第二段,表现为单个上皮细胞嗜酸性坏死和坏死后再生修复。 3、可以使全部大白鼠肾脏造成损害的最低剂量是每公斤体重0.1毫克硝酸铀酰;0.01—0.05毫克可以使一部分大鼠肾脏造成轻微的损害和变化。
1, this experiment examined a peritoneal injection of 1.0, 0.5, 0.001 mg of uranyl nitrate solution per kilogram body weight after 3, 7, 14, and 21 days after the histological changes of the kidney in rats. 2, and lethal dose of uranium poisoning, renal damage after a small dose of uranium poisoning is mainly located in the second part of the proximal curve of the labyrinthine, manifested as a single eosinophilic necrosis and necrosis of the regenerative repair. 3, the lowest dose that can cause damage to all rat kidneys is 0.1 mg of uranyl nitrate per kg of body weight; 0.01-0.05 mg can cause minor damage and changes to some of the rat kidneys.