总结了４０例低钾型周围性麻痹（ＨＯＫＰＰ）患者的临床资料。急性肌无力或麻痹伴急性低钾血症为其临床特点。原发性３０例，继发性１０例，其中甲亢９例。死亡３例。结合文献，对本病的病因、发病机理、诊断与鉴别诊断、治疗及预防进行了讨论。指出早期诊断和及时恰当治疗是降低病死率的关键。对继发性ＨＫＰＰ患者应强调病因治疗。 The clinical data of 40 patients with hypokalemic peripheral paralysis (HOKPP) were summarized. Acute myasthenia gravis or paralysis with acute hypokalemia is its clinical features. 30 cases of primary, secondary 10 cases, of which 9 cases of hyperthyroidism. 3 died. Combined with the literature, the etiology, pathogenesis, diagnosis and differential diagnosis, treatment and prevention of the disease were discussed. Pointed out that early diagnosis and timely and appropriate treatment is the key to reducing mortality. For secondary HKPP patients should emphasize the cause of treatment.