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目的探讨前庭功能锻炼对犬旋转刺激后血液神经内分泌指标的影响,阐明其与运动病的内在联系。方法 8只毕格犬,旋转刺激诱发运动病,测定呕吐潜伏期,同时用放射免疫分析法测定血浆皮质醇、促肾上腺皮质激素(ACTH)、精氨酸加压素(AVP)、肾上腺素与去甲肾上腺素水平。前庭功能锻炼3个月,观察呕吐潜伏期变化,再进行激素水平测定。结果 1)前庭功能锻炼后,呕吐潜伏期延长(P<0.01);2)前庭功能锻炼前,旋转刺激导致血浆皮质醇、AVP水平升高(P<0.05);3)前庭功能锻炼后,血浆皮质醇、AVP基础水平有所升高(P<0.05或0.01),但旋转刺激诱导的反应减弱;4)旋转刺激及前庭功能锻炼对血浆ACTH、肾上腺素与去甲肾上腺素水平无显著影响(P>0.05)。结论 1)前庭功能锻炼可以抑制运动病;2)旋转刺激可以引起血浆皮质醇、AVP水平升高;3)前庭功能锻炼可提高血浆皮质醇、AVP基础水平,但会减弱对运动病诱发刺激的反应。
Objective To investigate the effect of vestibular function training on blood neuroendocrine indexes after rotational stimulation in dogs and elucidate its intrinsic relationship with motion sickness. Methods Eight Beagle dogs were induced by rotational stimulation and the latency of vomiting was measured. Plasma cortisol, adrenocorticotropic hormone (ACTH), arginine vasopressin (AVP) and adrenaline were measured by radioimmunoassay Norepinephrine levels. Vestibular function training for 3 months to observe the changes of vomiting latency, and then determination of hormone levels. Results: 1) The vomiting latency was prolonged after vestibular function training (P <0.01); 2) Before the vestibular function training, rotational stimulation resulted in the increase of plasma cortisol and AVP levels (P <0.05); 3) After the vestibular function training, Alcohol and AVP (P <0.05 or 0.01), but the response induced by rotational stimulation was weakened. (4) Spin stimulation and vestibular function had no significant effect on plasma levels of ACTH, epinephrine and norepinephrine (P > 0.05). Conclusions 1) Vestibular functional exercise can restrain motion sickness; 2) Rotational stimulation can cause plasma cortisol and AVP levels to increase; 3) Vestibular functional exercise can improve the basic level of plasma cortisol and AVP, reaction.