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1980年以来我科所见儿童持续性低补体肾炎5例,皆为学龄儿童。3例以肾炎起病,2例以肾病综合征起病。起病时均有不同程度水肿,仅1例有高血压。尿检查均有红细胞及蛋白。4例血沉增高。作肾功能检查的4例均显示异常。全部病例血清C_2降低均持续8个月以上。尿免疫化学检查多数有大分子蛋白质(如C_2等)排出。1984年作末次随访,4例尿常规仍有改变,其中2例持续蛋白尿及血尿。血清C_2 3例恢复正常,2例仍明显低于正常。肾功能检查除1例有轻度尿浓缩功能受损外,余4例均正常,无一例出现持续高血压及氮质血症。根据ISKDC拟定的预测公式,本组4例计算结果,其病理类型皆符合膜性增殖性肾炎。
Since 1980, 5 cases of persistent low complement nephritis have been seen in our department, all of them are school-age children. 3 cases with nephritis onset, 2 cases with nephrotic syndrome onset. When onset have varying degrees of edema, only 1 case of hypertension. Urine examination have red blood cells and protein. 4 cases of erythrocyte sedimentation rate increased. 4 cases of renal function tests showed abnormalities. All cases of serum C 2 decreased for more than 8 months. Most urine immunochemical tests have macromolecular proteins (such as C_2) discharge. In 1984 for the last follow-up, 4 cases of urinary routine still change, of which 2 cases continued proteinuria and hematuria. Serum C_2 3 cases returned to normal, 2 cases were still significantly lower than normal. In addition to renal function tests in 1 case of mild dysfunction of urinary concentration, the remaining 4 cases were normal, no case of persistent hypertension and azotemia. According to the predictive formula developed by ISKDC, the results of 4 cases in this group, the pathological types are consistent with membranous proliferative glomerulonephritis.