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脑卡得平(Nicardipine,Yc—93)(简称NC)是一个新的二氢吡啶衍生物,结构与硝苯吡啶(Nifedipine,心痛定)相似。Takenaka等(1976)首先报道了NC对心血管的作用,并指出对脑部血管有选择性扩张作用。近几年来陆续报道NC的药理和临床应用的材料颇多。日本于1981年上市出售。本实验目的是研究江苏省医药工业研究所和南京制药厂1980年合成。性毒和理药的CN的
Nicardipine (Yc-93) (NC) is a new dihydropyridine derivative with a similar structure to nifedipine (nifedipine). Takenaka et al. (1976) first reported the effects of NC on cardiovascular system and pointed out the selective dilation effect on brain blood vessels. In recent years, one after another reported NC pharmacological and clinical application of a lot of material. Japan was put on the market in 1981. The purpose of this experiment is to study the synthesis of Jiangsu Institute of Pharmaceutical Industry and Nanjing Pharmaceutical Factory in 1980. Sexual toxicity and pharmacological CN