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目的探讨阿托伐他汀控制血脂的临床效果并对阿托伐他汀的药理作用进行总结。方法选择冠心病高脂血症患者86例,随机分为研究组和对照组,对照组43例给予辛伐他汀治疗,研究组43例给予阿托伐他汀治疗,对两组血脂水平进行比较。结果治疗后两组各项血脂指标均有改善,其中观察组TC、TG、LDL-C显著低于对照组,HDL-C则显著高于对照组,组间差异均具有统计学意义(P<0.05)。结论阿托伐他汀降血脂效果显著,临床选择降血脂药物可优先选用。
Objective To investigate the clinical effect of atorvastatin on lipids and to summarize the pharmacological effects of atorvastatin. Methods Eighty-six patients with coronary heart disease and hyperlipidemia were randomly divided into study group and control group, 43 patients in control group received simvastatin, and 43 patients in study group received atorvastatin treatment. Blood lipid levels were compared between the two groups. Results The levels of TC, TG and LDL-C in the two groups were all significantly improved after treatment. The levels of HDL-C and HDL-C in the observation group were significantly higher than those in the control group (P < 0.05). Conclusions Atorvastatin has a significant effect on lowering blood fat, and clinical choice of lipid-lowering drugs may be preferred.