[目的]研究急性脑梗死患者血浆内皮素(ET)水平的变化及其与病情预后的关系。[方法]78例急性缺血性脑梗死患者病程均在4 8h内,按梗死面积及神经功能缺损评分分为轻、中、重3组,分别于入院时、入院后3d、10d测定血浆内皮素水平并进行神经功能缺损评分。以2 5例健康体检者血浆内皮素水平作为正常对照组。[结果]3组患者内皮素水平均升高,其中以中、重组与正常对照组比较有显著性差异(P <0 .0 1) ;神经功能缺损评分越高,ET水平越高,且下降速度慢。[结论]脑梗死患者血浆内皮素水平均升高,与病情轻重及与病情进展相关,因此急性期测定ET水平,对判断病情、预后提供一个新的途径。 [Objective] To investigate the changes of plasma endothelin (ET) level and its relationship with the prognosis of patients with acute cerebral infarction. [Methods] The course of 78 patients with acute ischemic cerebral infarction were all within 48 hours. According to the infarction area and the neurological deficit score, the patients were divided into three groups: light, medium and heavy. At the time of admission and 3 days and 10 days after admission, the plasma endothelium Superoxide dismutase and neurological deficit scores. Serum endothelin levels in 25 healthy subjects were used as normal control group. [Results] The levels of endothelin in all three groups were significantly higher than those in the normal control group (P <0.01). The higher the neurological deficit score, the higher the ET level and the lower Slow. [Conclusion] The plasma endothelin levels in patients with cerebral infarction are both elevated and correlated with their severity and progression of disease. Therefore, the determination of ET level in acute phase provides a new way to judge the disease and prognosis.