论文部分内容阅读
关附甲素是从关白附子块根中提取的一种新生物碱。实验表明ＩＧＦＡＨ（５０ ｇ／ｍｌ）对大鼠离体心脏结扎冠脉诱发的室性心律失常有明显的保护作用，ＩＧＦＡＨ３、６、１２ｍｇ／ｋｇｉｖ能显著提高电刺激麻醉兔心室致颤阈值，ＩＧＰＡＨ１３．４，１６．８，２１．０ｍｇ／ｋｇｉｖ能明显对抗Ｃａｌ２－Ａｃｈ液诱发小鼠房扑（颤），其ＥＤ５０为１２．４±１．５ｍｇ／ｋｇ。ＩＧＦＡＨ１０，２５，４０ｍｇ／ｋｇｉｖ对乌头碱诱发的大鼠室性心律失常有明显的保护作用。ＩＧＦＡＨ小鼠ｉｖ的ＬＤ５０为１６３．９ｍｇ／ｋｇ，其９６％可信限为１５１．９—１７６．７ｍｇ／ｋｇ。
Guan A is a new alkaloid extracted from the roots of A. purpurea. Experiments showed that IGFAH (50 g / ml) had obvious protective effect on ventricular arrhythmia induced by ligating the coronary artery in rats. IGFAH 3, 6 and 12 mg / kgiv significantly increased the threshold of ventricular fibrillation induced by electrical stimulation in rabbits, and IGPAH13 .4,16.8,21.0mg / kgiv can obviously antagonize the atrial flutter (flutter) of mice induced by Cal2-Ach, the ED50 is 12.4 ± 1.5mg / kg. IGFAH10,25,40mg / kgiv on aconitine-induced ventricular arrhythmias had a significant protective effect. The LD50 of IGFAH mouse iv was 163.9 mg / kg with a 96% confidence limit of 151.9-176.7 mg / kg.