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目的监测江山市城区疑似预防接种异常反应(AEFI),分析预防接种的安全性,进一步规范预防接种行为。方法对疑似预防接种异常反应信息管理系统中2011—2013年江山市城区发生的所有AEFI病例进行分析。结果2011—2013年共发生AEFI病例68例,涉及13种疫苗,发生率35.04/10万,前3位为麻风疫苗(141.72/10万)、23价肺炎疫苗(125.16/10万)和无细胞百白破疫苗(79.05/10万)。临床诊断中,一般反应病例55例(80.9%),异常反应11例(16.1%),偶合症和心因性反应各1例(各1.5%);0、1、6岁组病例分别占27.9%、25.0%和14.7%;24h内发生者占88.2%。结论规范实施预防接种,提高接种人员综合素质,提高预防接种工作质量,可降低AEFI的发生率。
Objective To monitor the suspected anaphylactic vaccination (AEFI) in Jiangshan City, analyze the safety of vaccination and further standardize vaccination. Methods All cases of AEFI occurred in Jiangshan City in the period from 2011 to 2013 in the information system of suspected abnormal vaccination response were analyzed. Results A total of 68 AEFI cases were reported in 2011-2013, involving 13 kinds of vaccines at a rate of 35.04 / 100 000. The top three were leprosy vaccine (141.72 / 100000), 23 pneumococcal vaccine (125.16 / 100000) and cell free Baitai broken vaccine (79.05 / 100,000). In the clinical diagnosis, 55 cases (80.9%) were general reaction cases, 11 cases (16.1%) were abnormal reactions, 1 case (1.5% each) of couple and heart-cause reaction, and 27.9% %, 25.0% and 14.7%, respectively; 88.2% occurred within 24h. Conclusions The standardized implementation of vaccination, improve the overall quality of vaccination personnel, improve the quality of vaccination work, can reduce the incidence of AEFI.