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目的探讨血生殖激素水平在预测早期先兆流产预后中的价值。方法采用荧光酶免疫测定法对52例早期先兆流产,50例正常早孕妇女血绒毛膜促性腺激素(β-HCG)、孕酮(P)、雌二醇(E2)值进行测定。结果先兆流产妊娠持续组β-HCG、P、E2含量与对照组比较差异无统计学意义(P>0.05)。先兆流产妊娠失败组血β-HCG、P、E2含量显著低于对照组和妊娠持续组(P<0.01)。分别取β-HCG 180 IU/L,P 30 nmol/L,E220.5 nmol/L作为阈值,低于该阈值的β-HCG、P、E2预测先兆流产预后不良的敏感性分别为80%、80%、100%,特异性为78%、74%、83%,总符合率为79%、77%、91%。结论单次检测血β-HCG、P、E2对预测早期先兆流产的妊娠结果是有价值的。
Objective To investigate the value of blood reproductive hormones in predicting the prognosis of threatened abortion. Methods The serum levels of β-HCG, progesterone (P) and estradiol (E2) were measured in 52 cases of early threatened abortion and 50 normal pregnant women by fluorescence enzyme immunoassay. Results The levels of β-HCG, P and E2 in the persistent gestational threatened abortion group were not significantly different from those in the control group (P> 0.05). The levels of serum β-HCG, P and E2 in the failed pregnancy induced by threatened abortion were significantly lower than those in the control group and the continuous pregnancy group (P <0.01). The sensitivity of β-HCG 180 IU / L, P 30 nmol / L and E220.5 nmol / L as threshold values, β-HCG, P and E2 below the threshold were 80% 80%, 100%, specificity of 78%, 74%, 83%, the total coincidence rate of 79%, 77%, 91%. Conclusion Single detection of serum β-HCG, P, E2 is valuable in predicting pregnancy outcome of early threatened abortion.