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国外大量观察和研究发现消化性溃疡与体内多巴胺缺乏密切相关。由此,作者对103例消化性溃疡患者用L—dopa和Cimetidine进行了双盲对照研究,旨在了解L—dopa的抗溃疡作用,开拓消化性溃疡药物治疗的新途径。其中L—dopa组54例,完全随机分为三组,分别给予L—dopa 0.25 Bid,0.25qid,0.5 tid;对照组49例,给予口服Cimetidine0.2 tid,夜晚睡前加服0.4。疗程均为4周。结果表明,L—dopa对消化性溃疡腹痛的缓解率为90.8％,而抗溃疡作用则是剂量依赖性的,口服0.25 qid组和0.5 tid组溃疡愈合率与Cimetidine组溃疡愈合率差异无显著性(P>0.05),且无明显副作用。对L—dopa的抗溃疡作用机理进行了讨论。因此,作者认为L—dopa不失为一种有效、廉价、副作用小的抗溃疡药物,使用剂量以0.25qid为宜。
A large number of foreign observation and study found that peptic ulcer and the body is closely related to the lack of dopamine. Thus, the authors of 103 patients with peptic ulcer with L-dopa and Cimetidine double-blind controlled study aimed to understand the anti-ulcer L-dopa role, open up new avenues of peptic ulcer drug treatment. Among them, 54 patients in L-dopa group were randomly divided into three groups, which were given L-dopa 0.25 Bid, 0.25qid and 0.5 tid respectively. In control group, 49 patients received oral Cimetidine 0.2 tid and night before bedtime. The course of treatment is 4 weeks. The results showed that L-dopa alleviated abdominal pain of peptic ulcer with a rate of 90.8%, while the anti-ulcer effect was dose-dependent. There was no significant difference between the healing rate of ulcer in 0.25 qid group and 0.5 tid group and the healing rate of ulcer in Cimetidine group (P> 0.05), and no obvious side effects. The anti-ulcer mechanism of L-dopa is discussed. Therefore, the authors believe that L-dopa after all, an effective, cheap, anti-ulcer drugs with small side effects, the dose to 0.25qid appropriate.