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本文报导六氯邻二甲苯()的急慢性毒性。急性毒性试验用42只体重20～27 g小鼠,35只体重150～190 g大鼠和30只体重1.8～3.0 kg家兔,药物以葵花子油制成混悬液,用胃管灌胃。亚急性毒性和慢性毒性试验用大鼠和家兔,药物以葵花子油制成混悬液灌胃。亚急性毒性剂量分别为1/10、1/50、1/250、1/500、1/1250和1/2500 LD_(50),测定给药前和给药后5、10、20、30和45天动物血象和生化指标,并研究其蓄积作用。慢性毒性试验剂量为1/250、1/1250和1/2500 LD_(50),每日给药一次,连续6个月,测定给药前、给药后
This article reports the acute and chronic toxicity of hexachloro-o-xylene (). Acute toxicity tests were performed in 42 mice weighing 20-27 g, 35 rats weighing 150-190 g and 30 rabbits weighing 1.8-3.0 kg. The drug was made into a suspension with sunflower oil, and was administered by gastric tube. Subacute toxicity and chronic toxicity tests were performed in rats and rabbits by intragastric administration of the drug as a suspension in sunflower oil. Subacute toxic doses were 1/10, 1/50, 1/250, 1/500, 1/1250 and 1/2500 LD_ (50), respectively, before and after administration of 5,10,20,30 and 45 days animal blood and biochemical indicators, and study its accumulation effect. Chronic toxicity test dose of 1/250, 1/1250 and 1/2500 LD_ (50), administered once daily for 6 months, before and after administration