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选择1994年6月1日至1996年6月1日我院收治的先兆子痫患者84例,随机分为两组,分别给予硫酸镁和酚妥拉明治疗。结果显示:用药30分后酚妥拉明组舒张压均值下降3.0kPa,而硫酸镁组几无下降,差异有显著性(P<0.05)。酚妥拉明组用药后30分血压即明显下降,而硫酸镁组用药2小时后才显著下降。酚妥拉明组平均疗程(36.24±11.71)h,明显短于硫酸镁组的(57.63±19.18)h(P<0.05)。胎儿宫内窘迫发生率为12.20％(5/41),亦明显低于硫酸镁组30.23％(13/43)(P<0.05),但两组新生儿窒息率差异无统计学意义(P>0.05)。因此认为酚妥拉明治疗先兆子痫能使血压迅速下降,平均疗程明显缩短,同时避免药物对BPS评分的干扰,有利于正确估计胎儿的宫内情况,便于为终止妊娠选择良好时机。
84 patients with preeclampsia who were admitted to our hospital from June 1, 1994 to June 1, 1996 were randomly divided into two groups, which were treated with magnesium sulfate and phentolamine respectively. The results showed that after 30 minutes of administration, mean diastolic pressure of phentolamine group decreased by 3.0 kPa, while there was no difference in magnesium sulfate group (P <0.05). Ptoleptram group 30 minutes after administration of blood pressure decreased significantly, while the magnesium sulfate group medication 2 hours after significant decline. The average course of treatment of Phentolamine group (36.24 ± 11.71) h was significantly shorter than that of magnesium sulfate group (57.63 ± 19.18) h (P <0.05). The incidence of fetal distress was 12.20% (5/41), also significantly lower than that of magnesium sulfate group (30.23%, 13/43) (P <0.05), but there was no significant difference in neonatal asphyxia between the two groups (P> 0.05). Therefore, the treatment of pre-eclampsia phentolamine can make the blood pressure decreased rapidly, the average course of treatment was significantly shortened, while avoiding the interference of drugs on the BPS score is conducive to the correct estimation of fetal intrauterine conditions, to facilitate the termination of pregnancy to choose a good time.