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恶性疟原虫钙ATP蛋白6(Plasmodium falciparumcalcium ATPase 6,PfATP6)是青蒿素及其衍生物作用靶点之一,PfATP6是一类肌浆网/内质网钙ATP酶(sarco/endoplasmic reticulum calcium ATPase,SERCA),它通过消耗ATP来调节疟原虫胞浆内钙离子浓度,保持钙浓度的内稳状态。青蒿素及其衍生物通过抑制PfATP6,从而引发疟原虫胞浆内钙离子浓度上升,起到杀疟作用;疟原虫也通过PfATP6基因突变出现耐药现象。青蒿素及其衍生物通过对肿瘤细胞的SERCA抑制,引发肿瘤细胞内钙离子浓度的变化,激活凋亡程序,导致肿瘤细胞死亡;还能通过抑制SERCA治疗刚地弓形虫、巴贝斯虫和耶氏肺孢子菌感染,使PfATP6/SERCA基因研究更为重要,青蒿素及其衍生物临床应用更为广泛。
Plasmodium falciparumcalcium ATPase 6 (PfATP6) is one of the targets of artemisinin and its derivatives. PfATP6 is a sarco / endoplasmic reticulum calcium ATPase , SERCA), which regulates calcium concentration in the cytoplasm of Plasmodium by consuming ATP to maintain the homeostasis of calcium concentration. Artemisinin and its derivatives through the inhibition of PfATP6, resulting in plasmodial plasmodium Ca2 + concentration rise, play a malaria; Plasmodium also by PfATP6 gene mutation resistance phenomenon. Artemisinin and its derivatives through the SERCA inhibition of tumor cells, triggering changes in the concentration of calcium ions in tumor cells, activating the apoptosis program, resulting in tumor cell death; but also by inhibiting SERCA treatment of Toxoplasma gondii, Babesia and Yersinia pneumoniae infection, PfATP6 / SERCA gene research is more important, artemisinin and its derivatives are more widely used in clinical practice.