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目的 :探讨白芍总甙 (TGP)对离体豚鼠结肠平滑肌的作用方式及对结肠平滑肌中 P物质 (SP)和血管活性肠肽 (VIP)释放的影响。方法 :观察不同剂量 TGP及工具药对离体结肠肌收缩活性的效应及利用 SABC法检测结肠平滑肌中 SP和血管 VIP的变化。结果 :TGP使豚鼠结肠离体平滑肌收缩积分和时间显著性增加 ,且收缩效应的改变具有剂量依赖性。平滑肌中 SP的反应显著性增强。结论 :TGP可通过延长结肠收缩时间 ,增强结肠收缩幅度而调节结肠运动 ,SP是 TGP作用的递质之一。
Objective : To explore the effect of total peony (TGP) on the colonic smooth muscle of guinea pigs and the effect on the release of substance P (SP) and vasoactive intestinal peptide (VIP) from colonic smooth muscle. Methods : To observe the effect of different doses of TGP and TCM on the contractile activity of isolated colon muscles and to detect the changes of SP and vascular VIP in colonic smooth muscle using SABC method. RESULTS: TGP significantly increased the systolic score and time of isolated colon smooth muscle in guinea pigs, and the change of contractile effect was dose-dependent. The response of SP in smooth muscle is significantly enhanced. Conclusion: TGP can regulate colonic movement by prolonging the contraction time of the colon and increasing the contraction of the colon. SP is one of the transmitters of TGP.