慢性阻塞性肺疾病(COPD)发病机制尚未完全清楚,呼吸道细胞外基质(ECM)重塑,是COPD不可逆性气流受限的重要病理基础。基质金属蛋白酶(MMPs)可降解肺泡壁ECM和基底膜几乎所有的蛋白成分,参与呼吸道重建。本文就MMP-9的来源、基因定位、结构功能、调节机制,近年来临床研究、动物模型研究、基因多态性方面研究的发现简要综述,探讨MMP-9在COPD发病机制中的作用。 The pathogenesis of chronic obstructive pulmonary disease (COPD) is not yet fully understood. Remodeling of extracellular matrix of the respiratory tract (ECM) is an important pathological basis for the irreversible airflow limitation in COPD. Matrix metalloproteinases (MMPs) can degrade almost all of the protein components of the alveolar wall ECM and basement membrane, and participate in airway remodeling. This review summarizes the findings of MMP-9 in origin, gene localization, structural function, regulatory mechanism, recent clinical studies, animal model studies and genetic polymorphisms, and explores the role of MMP-9 in the pathogenesis of COPD.