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涎腺黏膜相关淋巴组织淋巴瘤的发病与免疫和慢性感染密切相关,如舍格伦综合征和慢性自身免疫性甲状腺炎以及丙型肝炎病毒、E-B病毒、人类疱疹病毒、人类嗜T淋巴细胞病毒和人类免疫缺陷病毒感染。该病通常无染色体易位,但与某些化学增活素和良性淋巴上皮病变有关,染色体增殖方式较为保守且增加多于丢失,其靶基因表现为积极地调整细胞的寿命和增殖。该病的临床表现为无痛,病程迁延,需要长期地观察和反复活检方能确诊,放射和化学治疗均敏感,多病灶者常需多种手段的联合治疗。该病预后较好,复发率较其他黏膜相关淋巴组织淋巴瘤高,还有可能伴发涎腺肿胀症、肌上皮涎腺炎和二次癌症以及远处播散,甚至累及骨髓,长时间、仔细地观察随访对其预后十分重要。
The incidence of salivary mucosa-associated lymphoid tissue lymphoma is closely related to immunity and chronic infection, such as Sjogren’s syndrome and chronic autoimmune thyroiditis, as well as hepatitis C virus, Epstein-Bar virus, human herpesvirus, human T-lymphotropic virus And human immunodeficiency virus infection. The disease is usually chromosomally translocated, but is associated with certain chemokines and benign lymphoepithelial lesions. Chromosomal proliferation is more conserved and more than lost, and its target genes are shown to actively modulate cell longevity and proliferation. The clinical manifestations of the disease is painless, duration of the disease, the need for long-term observation and repeated biopsy can be diagnosed, radiation and chemotherapy are sensitive to multiple lesions often require a combination of means of treatment. The prognosis of the disease is better, the recurrence rate is higher than other mucosa-associated lymphoid tissue lymphoma, there may be associated with salivary gland swelling, sarcoidosis and secondary myeloma and disseminated distant cancer, and even involving the bone marrow for a long time, A careful observation of follow-up is very important for its prognosis.